First version 1991, last update June 1999
Document homepage tryp.net
Thanks to many individuals for help in putting this together!
If you know sources of tryptamines that are not mentioned here or have other comments please mail me.
Also See: DMT
Psychotropic Tryptamine Derivatives
|Name of Compound||R2||N1||N2||alpha||R4||R5||R6||Dosage
|Typical effects in mentioned dose range|
|Severe physical symptoms|
(@ Deoxy, @ Erowid, @ Lycaeum)
|H||CH3||CH3||H||H||H||H||30-100||par||up to 1|
|Intense psychedelic and hallucinogenic|
|Tactile sensitivity increased, sound distortion|
|Psychedelic, more earth-bound and less abstract than LSD. Not a stimulant. Phosphate ester is psilocybin.|
|Severe physical symptoms.|
|Intense psychedelic, less visual than DMT|
|Sense-enhancing psychedelic, significant physical side-effects at high doses|
|Similar to psilocin|
|DET (@ Erowid)||H||C2H5||C2H5||H||H||H||H||50-100||oral||2-4|
|Sound distortion, more cloudy than 2-Me-DMT|
|Psychedelic with significant physical side-effects at high doses.|
|Sense-enhancing psychedelic with heavy physical symptoms|
|DET-like effects in one report|
|DPT (@ Erowid)||H||n-prop||n-prop||H||H||H||H||60-250||oral||2-4|
|Psychedelic with significant physical side-effects at high doses|
|Auditory distortion and -hallucinations|
|Intense and dose-sensitive psychedelic, mild physical symptoms|
|5-MeO-DIPT (@ Erowid)||H||i-prop||i-prop||H||H||OCH3||H||6-12||oral||4-8|
|Sense-enhancing psychedelic with some auditory distortion|
|MIPT (@ Erowid)||H||i-prop||CH3||H||H||H||H||10-25||oral||3-4|
|Stimulating, sense-enhancing psychedelic|
|Sense-enhancing psychedelic, not stimulating|
|Some light-headedness at 75 mg|
|Slightly psychedelic with dysphoric components and nausea|
|Some amphetamine-like lightheadedness, loss of appetite|
|Somewhat uninspiring psychedelic|
|Slightly hallucinogenic with heavy physical symptoms|
|AMT, IT-290 (@ Erowid)||H||H||H||CH3||H||H||H||15-30||oral||12-16|
|Stimulating psychedelic with little visuals and significant physical symptoms at high doses|
|Dizzy hallucinogen severe physical symptoms|
|Potent MAOI, an antidepressant rather than a psychedelic.|
|Psychedelic, slight nausea or diarrhea at about 1 hour|
|Euphoric entactogenesis. Potential treatment for opiate withdrawal.|
|Some psychedelia with stimulant effects|
|Neurotransmitter, does not pass the blood-brain-barrier. Cardiovascular and autonomic symptoms.|
|Dizzy psychedelia with severe physical symptoms|
|Severe physical symptoms, anaesthesia|
|Subtle psychedelia, not a stimulant|
|Unknown, also holds for the i-propyl version (NIPT)|
|Unknown, also holds for the i-butyl version (NIBT)|
|Generalized and diffuse intoxication|
|Light headed, pleasant intoxication (similarities to GHB)|
|4,alpha-DMT, MP 809||H||H||H||CH3||H||CH3||H||60||oral||?|
|An antidepressant rather than a psychedelic|
|Induces sleep, resets circadian rhythm. An antioxidant.|
MAO inhibitors fall into two classes: Irreversible and reversible MAOIs. In addition they can inhibit either or both of the two types of the MAO enzyme, MAO-A and MAO-B which are associated with serotonergic and dopaminergic neurons respectively. Irreversible MAOIs (e.g. the hydrazides iproniazid and phenelzine) bind permanently to the enzyme and cause MAO inhibition lasting 1-2 weeks after ingestion. They are used clinically to treat depression. Reversible MAOIs, such as moclobemide, which is used as an antidepressant, and the beta-carbolines harmine and harmaline, are effective for much shorter time, maybe up to 24 hours. Recreational drug users around the world are using mainly harmine and harmaline despite the lack of scientific studies on their effects on humans.
Natives of Amazon have traditionally combined Banisteriopsis caapi vine, which contains harmine, harmaline and related beta-carbolines, with DMT-containing plants to make an orally active brew called ayahuasca (@ Erowid). Other plants containing harmine and/or harmaline can be substituted for B. caapi. The usual 'North American ayahuasca' consists of Peganum harmala ( picture, another picture, seeds and Desmanthus illinoensis roots, and in Australian 'acaciahuasca' leaves of Acacia complanata are combined with material from DMT-containing acacias (the effectivity of this mixture hasn't been confirmed). Nausea is minimized in 'pharmahuasca', which consists of pure DMT and a reversible MAO-inhibitor such as harmine or moclobemide. When the DMT is in a plant extract taking it with a pure MAO inhibiting substance instead of a plant containing MAOIs usually reduces nausea and other body load significantly. MAOIs have also been used to potentiate the effects of mushrooms containing psilocybin and even phenethylamines -- the latter combination can be very dangerous. DPT ingested with MAOIs has been called 'propylhuasca'; DPT is orally active by itself and its dosage should be smaller when potentiated by MAOIs.
Peganum harmala (Syrian rue) seeds - pictured - are the most concentrated natural source of harmine and harmaline - about 3% of their weight consists of these alkaloids. Banisteriopsis caapi has been found to contain from 0.18% to 1.36% beta-carbolines, with the concentration of harmine being from 0.057% to 0.635% (McKenna et al. 1984). According to anecdotal reports one gram (corresponding to approx. 30 mg of harmine/harmaline) of P. harmala seeds ingested inhibits MAO enough to make DMT orally active, while 75 mg of moclobemide is sufficient for the same purpose.
Harmine and harmaline are hallucinogenic on their own with doses starting from around 300 mg (Naranjo 1967), but often cause physical side-effects such as nausea and tremors in this dose range. They have little emotional or 'psychedelic' effects, but produce strong visual hallucinations. Because of this the natives of Amazon often add larger amounts (75-100 cm of stem per dose) of B. caapi to ayahuasca brew than is needed for MAO inhibition (Luna 1984). The psychedelic effects of moclobemide at normal antidepressant doses (e.g. 150 mg/day) are limited to slight hallucinations of the sense of balance, which is rarely affected by other drugs.
A combination of a MAO inhitor and DMT tends to induce drowsiness. Perhaps this is why natives often smoke tobacco and/or drink caffeine-containing drinks while preparing and tripping on ayahuasca. The MAO-B inhibition of nicotine might also be a reason for smoking it, although it is unclear to which extent inhibition of just MAO-B activates or potentiates tryptamines.
There are significant dangers in using MAO inhibitors. Most MAOIs potentiate the cardiovascular effects of tyramine and other monoamines found in foods. Ingestion of aged cheese, beer, wine, pickled herring, chicken liver, yeast, large amounts of coffee, citrus fruits, canned figs, broad beans, chocolate or cream while MAO is inhibited can cause a hypertensive crisis including a dangerous rise in blood pressure. You can also look at a more complete list of foods to avoid when receiving MAOI therapy. MAOIs interact with other psychoactive substances in addition to tryptamines; effects of amphetamines, general anaesthetics, sedatives, anti-histamines, alcohol, potent analgesics and anticholinergic and antidepressant agents are prolonged and intensified. Overdosage of MAOIs by themselves is also possible with effects including hyperreflexia and convulsions. It should be noted, however, that these strict warnings apply best in the case of irreversible MAOIs, and many users of reversible MAOIs to activate or potentiate tryptamines are not quite as careful with no apparent ill effects.
So, ingesting l-tryptophan to increase serotonin levels, a candy bar to increase the amount of tryptophan getting to your brain and natural plant material containing 25-50 mg harmine/harmaline to block MAO, all at the same time, might cause your pineal gland to synthesize substantial amounts of 5-MeO-DMT (Most 1986). Similar results might be obtained by substituting 5-hydroxytryptophan (5-HTP) for tryptophan. Normal sleep-inducing doses of melatonin have also been taken with reversible MAOIs with the resulting psychoactive effects suggesting significant interaction of the two substances. This is extremely dangerous for persons with existing amine imbalance or schizophrenia. For normal, healthy people possible consequences are bad.
A potent inhibitor of INMT, which is a necessary enzyme for the synthesis of DMT and 5-MeO-DMT, is found in particularly high concentrations in the pineal gland. A bypassing or inhibition of the synthesis of this inhibitor might be responsible for trances and other psychedelic states achieved "without drugs" (Strassman 1990). See Strassman's article for more info and speculation about the pineal gland.
Many animals, including mammals, contain psychoactive tryptamines. Below are two examples.
Fresh venom can easily be collected without harm to the toad. Use a flat glass plate or any other smooth, nonporous surface at least 12-inches square. Hold the toad in front of the plate, which is fixed in a vertical position. In this manner, the venom can be collected on the glass plate, free of dirt and liquid released when the toad is handled.Davis and Weil (1992) smoked the venom and described what happened:
When you are ready to begin, hold the toad firmly with one hand and, with the thumb and forefinger of your other hand, squeeze near the base of the gland until the venom squirts out of the pores and onto the glass plate. Use this method to systematically collect the venom from each of the toad's granular glands: those on the forearm, those on the tibia and femur of the hind leg, and, of course, the parotids on the neck. Each gland can be squeezed a second time for an additional yield of venom if you allow the toad a one-hour rest preiod. After this the glands are empty and require four to to six weeks for regeneration.
The venom is viscous and milky-white in color when first squeezed from the glands. It begins to dry within minutes and acquires the color and texture of rubber cement. Scrape the venom from the glass plate, dry it thoroughly, and store it in an airtight container until you are ready to smoke it.
In comparison to the pure compounds the toad venom appears longer lasting and, because one does not completely lose contact with reality, far more pleasant, even sensual. Shortly after inhalation I experienced warm flushing sensations, a sense of wonder and well-being, strong auditory hallucinations, which included an insect-cicada sound that ran across my mind and seemed to link my body to the earth. Though I was indoors, there was a sense of the feel of the earth, the dry desert soil passing through my fingers, the stars at midday, the scent of cactus and sage, the feel of dry leaves through hands. Strong visual hallucinations in orblike brilliance, diamond patterns that undulated across my visual field. The experience was in every sense pleasant, with no disturbing physical symptoms, no nausea, perhaps a slight sense of increased heart rate. Warm waves coursed up and down my body. The effects lasted only a few minutes but a pleasant afterglow continued for almost an hour. (Wade Davis, personal observation, January 12, 1991)Other animals contain DMT such as the gorgonian Paramuricea chamaeleon (Cimino & De Stefano, 1978).
Profound alteration of consciousness within a few seconds of exhaling. I relax into a deep, peaceful interior awareness. There is nothing scary about the effects and no sense of toxicity. I try to describe my feelings but am unable to talk for the first five minutes and then only with some difficulty. This is a powerful psychoactive drug, one that I think would appeal to most people who like the effects of hallucinogens. For the next hour I feel slow and velvety, with a slight pressure in my head. No long-lasting effects to report. (Andrew T. Weil, personal observation, January 12, 1991).
The psychoactive tryptamines in fungi are mainly psilocybin and psilocin although others are also present. Paul Stamets has compiled a comparison of combined maximum percentages of psilocybin, psilocin and baeocystin in 11 species of Psilocybe.
Images of Psilocybe azyrescens, baeocystis, cubensis, cyanescens, cyanofibrillosa, azurescens, pelliculosa, semilanceata, silvatica, stuntzii and weilii can be seen at
A Gallery of Psilocybe Mushrooms
The trees grow in open plain areas, and leaves, bark and seeds contain DMT, 5-MeO-DMT and related compounds (Schultes 1976, 1977; Pachter et al. 1959; Phytochem 11, 737). Smoking half a gram of A. colubrina seeds has been reported to give a mild psychedelic effect.
Amazonian Colombia natives roll small pellets of boiled resin in a evaporated filtrate of bark ashes of Gustavia Poeppigiana and ingest them to bring on a rapid intoxication (Smith 1977, Schultes 1977).
Jim DeKorne (1996) has reported that strong varieties of P. Arundinacea can be processed simply with a wheatgrass juicer to yield a liquid that is potent enough for one teaspoon to be effective with MAOIs. He has prepared a potent smokable extract as follows: grass clippings are pulverized and water is added to make a pourable mixture, which is then acidified to about pH 5. The mix can then be heated overnight while evaporation is not allowed. The plant matter is separated by first using a cheesecloth and then a paper coffee filter. 10-15% of the mass of the resulting solution of a "defatting solvent" (e.g. methylene chloride, ether, chloroform, or naptha) is then added. After vigorous shaking the water containing the alkaloids is separated from the solvent. A base is added to the aqueous solution in small increments until the pH gets to about 9 or 10, which converts the alkaloids into their free base. Extraction is then performed four times with an organic solvent, comprising 10% of the mass of the solution, first after 24 hours and then at three weekly intervals, while the solvent layer takes on a darker tint (usually yellowish or reddish-brown). In total the extraction takes almost a month and the solution should be shaken at least twice a day between extractions. To isolate the alkaloids the solvent is finally evaporated from the combined extract fractions.
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* Everything is perfect forever [-P.P.]
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© Petrus Pennanen 1999
* Ditto [-M.]
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Ott, J. 1994. Ayahuasca Analogues. Natural Products Co..
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* Everything is perfect forever [-P.P.]