Definition: Clone A recombinant DNA molecule containing a gene or other DNA sequence of interest. Also, the act of generating such a molecule. Usage: "to isolate a clone" or "to clone a gene." And, as defined in "The Human Genome Project," Los Alamos Science , Number 20 1992: 1. A population of genetically identical unicellular organisms or viruses arising from successive replications of a single ancestral unicellular organism or virus. r &Q 2. A recombinant clone. 3. The fragment of foreign DNA contained in each member of a recombinant clone. 4. A population of identical cells arising from the culture of a single cell of a certain type, such as a human fibroblast or a rodent-human hybrid cell containing a full set of rodent chromosomes and a single human chromosome.